Yu-Gi-Oh! 5D's: The Seventh Signer is a sequel series that follows after the events of Yu-Gi-Oh! 5D's. As well as the anime series, this series takes some inspiration from:
- Yu-Gi-Oh! 5d's Tag Force 4
- Yu-Gi-Oh! 5d's Tag Force 5
- Yu-Gi-Oh! 5d's Tag Force 6
- Yu-Gi-Oh! 5d's World Championship 2009: Star Accelerator
- Yu-Gi-Oh! 5d's World Championship 2010: Reverse of Arcadia
- Yu-Gi-Oh! 5d's World Championship 2011: Over the Nexus
- Yu-Gi-Oh! 5d's Duel Transfer
- Jacen Dzunk (Janūsu Zephyr) - The main protagonist, a prisoner at the facility for trespassing in similar fashion that Yusei did through the pipeline, but was caught upon escaping through to New Domino from Satelite. He is struggling between both signer marks choosing him and refuses to take sides.
- Scrap Dragon (Sukurappu Doragon) - Jacen's Signer Dragon, embodied in his Body Mark of the Dragon under his right arm. His signer ability grants Jacen telepathy that gives him the ability to talk to both signer mark spirits. Doubling with Chuka Raba's ability, allows him to make both spirits real.
- Earthbound Immortal Chuka Raba (Jibakushin Suchuk Rupa) - Jacen's Earthbound Immortal, embodied in his Coyote Mark of the Shadows on his left arm down his shoulder. His signer ability grants Jacen thought projection that gives him the ability to conjour an image of what ever he thinks of. Doubling with Scrap Dragon's ability, allows him to make both spirits real.
- Yusei Fudo (Fudō Yūsei) -
- Stardust Dragon (Sutādasuto Doragon) - Yusei's personal card, and signer dragon. Embodied in his head (formally tail) signer mark.
- Jack Atlas (Jakku Atorasu ) - Jack's personal card, and signer dragon. Embodied in his wings signer mark
- Red Dragon Archfiend (Reddo Dēmonzu Doragon) -
- Crow Hogan (Kurou Hōgan) - Crow's signer dragon. Embodied in his tail signer mark.
- Black-Winged Dragon (Burakkufezā Doragon) -
- Akiza Izinski (Aki Izayoi) - (mentioned)
- Black Rose Dragon (Burakku Rōzu Doragon) -
- Luna Sawatori (Sāwatōri Ruka) - (mentioned)
- Ancient Fairy Dragon (Enshento Fearī Doragon) -
- Leo Sawatori (Sāwatōri Rua) - (mentioned)
- Life Stream Dragon (Raifu Sutorīmu Doragon) -
- Robert Pearson (Robāto Piasun)
- Earthbound Immortal Wiraqocha Rasca (Jibakushin Wirakocha Rasuka) -
- Sayer (Divain)
- Earthbound Immortal Uru (Jibakushin Uru) -
- Toby Tredwell (Tobi Rola) -
- Earthbound Immortal Cusillu (Jibakushin Kushiru)
- Earthbound Immortal Ccarayhua (Jibakushin Kokaraia)
- Earthbound Immortal Ccapac Apu (Jibakushin Kokapaku Apu)
- Earthbound Immortal Aslla Piscu (Jibakushin Asura Pisuku)
- Earthbound Immortal Chacu Challhua (Jibakushin Chaku Charua)